New research suggests that people who discontinue popular slimming jabs like Wegovy and Mounjaro tend to recover shed pounds at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Published data in a major health publication shows that while obese individuals can lose about a fifth of their total mass while undergoing treatment, the weight returns at an average rate of 0.8 kg per month once they quit.
"People purchasing these medications should be cognizant of the danger of quick weight regain when the treatment ends," stated researcher Dr. Susan Jebb.
That rate of recovery suggests a return to original weight within about 18 months.
Comparing Treatments
The analysis, which reviewed dozens of trials involving over 9,000 of participants, compared the results of the injectable medications with conventional dieting.
The team point out that people who shed pounds through lifestyle changes alone usually see a more gradual creep back—perhaps 100 grams monthly—once they finish.
Understanding the Fast Rebound
Doctors suggest the mechanism of the injections explains the amplified regain.
The injections copy a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 levels far above than the body's typical production may cause the body to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication results in appetite is uncontrolled, making overeating a significant risk."
A Chronic Condition?
The NHS suggest the jabs for people with obesity-related health risks, accompanied by prescribed lifestyle changes.
Professionals argue that, considering the significant potential of relapse, the therapy might need to be life-long.
This perspective is reinforced by drug manufacturers, who state that the findings "emphasize the persistent character of obesity," akin to managing diseases like high blood pressure.
Patient Accounts
Users who have stopped the medication report a intense return of appetite.
"It was like something flipping and I was suddenly extremely hungry," recalled a patient.
This challenge is exacerbated if individuals have not adopted permanent dietary or behavioural modifications during treatment.
Significant Interest
Figures indicate that millions of people in the UK have used these injections in the past year, with interest being substantial.
- Adoption is more common among females compared to men.
- The 40s and 50s age group shows the highest usage rates.
- Many access the medications through private prescriptions rather than public health services.
Ultimately, experts caution that while the jabs are powerful agents for shedding pounds, they are not a magic cure and maintained weight loss relies on integrated behavioural support.
